Retail

Prime Retail Space on First Avenue – 626 First Ave, Murray Hill / Midtown East

Address: 626 First Avenue, New York, NY, 10016
Price: $120,000/month
Square Feet: 7,535 SF
Type: Retail Space

Property Overview:

Located on First Avenue in the Murray Hill / Midtown East neighborhood — one of Manhattan’s most convenient, centrally located, and desirable residential and commercial areas — 626 First Avenue offers 7,535 SF of expansive retail space at a premium price befitting this high-traffic corridor. Ideal for fitness centers, medical facilities, urgent care centers, big-box retail, grocery markets, showrooms, or service-based businesses. Situated between East 37th Street and East 38th Street, this space benefits from proximity to major hospitals, the United Nations, Grand Central Terminal, and some of the city’s best dining, shopping, and transit.

Key Features:

Prime Murray Hill / Midtown East / First Avenue Location:

• Situated on First Avenue, a major north-south thoroughfare that serves as a commercial spine for Murray Hill and Midtown East — two of Manhattan’s most convenient, centrally located, and desirable residential and professional areas, known for their pre-war architecture, tree-lined streets, strong sense of community, and excellent transit access .
• Located between East 37th Street and East 38th Street, placing your business in a high-traffic corridor with constant foot traffic from local residents, office workers, medical professionals, and commuters.
• Just steps from NYU Langone Medical Center (First Avenue between 30th-34th Streets), Bellevue Hospital (First Avenue and 29th Street), and VA NY Harbor Healthcare System — creating consistent demand for medical practices, urgent care, pharmacies, and patient-serving retail.
• Minutes from Grand Central Terminal (42nd Street and Park Avenue — a 15-minute walk), Murray Hill’s vibrant dining and nightlife scene, and the East River Esplanade .

Medical & Institutional Proximity – A Healthcare Hub:

• Located within easy reach of several major medical institutions:
• NYU Langone Medical Center (First Avenue between 30th-34th Streets)
• Bellevue Hospital (First Avenue and 29th Street)
• VA NY Harbor Healthcare System
• Hospital for Joint Diseases (NYU Langone Orthopedic) (17th Street and Second Avenue)
• This concentration of world-class hospitals and research centers creates consistent, high-demand foot traffic from medical professionals, hospital employees, patients, families, and caregivers — all needing nearby medical services, pharmacies, and patient-serving retail.

Expansive & Flexible Retail Layout – 7,535 SF:

• 7,535 SF of generous retail space — one of the largest available retail footprints in Murray Hill / Midtown East, ideal for a fitness center, medical facility, urgent care center, pharmacy, grocery market, or big-box retail.
• Attractive storefront with excellent street-level visibility on First Avenue, a busy corridor with constant pedestrian and vehicular flow.
• High ceilings and open floor plan with minimal columns, allowing for easy customization to fit various business needs — from fitness equipment and exam rooms to retail displays and checkout lanes.
• Large windows providing abundant natural light — a valuable feature for patient-facing medical practices and wellness studios.
• Potential for back-of-house space, storage, office areas, or a kitchen depending on configuration.
• Loading access available — ideal for grocery markets, entertainment concepts, or wholesale operations requiring frequent deliveries.
• At $15.93 per square foot, this price reflects the premium nature of this high-demand location — competitive for this prime Midtown corridor.

Excellent Transit Access:

• Close to Grand Central Terminal (4, 5, 6, 7, S) — a 15-minute walk — providing direct access to Metro-North Railroad and multiple subway lines, one of Manhattan’s busiest and most convenient transit hubs.
• Moments from the 33rd Street subway station (6) on Park Avenue and the 34th Street – Herald Square station (B, D, F, M, N, Q, R, W) .
• Short walk to Penn Station (1, 2, 3, A, C, E) , providing LIRR, NJ Transit, and Amtrak connections.
• Multiple bus routes serve First Avenue, Second Avenue, and 34th/37th Streets (M15, M34-SBS, M34A, M101, M102, M103).
• Convenient for medical professionals, patients, and families from all five boroughs, Westchester, Long Island, New Jersey, and beyond.

Diverse, High-Demand Customer Base:

• Medical professionals — thousands of doctors, nurses, researchers, and administrators employed at nearby world-class hospitals (NYU Langone, Bellevue, VA, Hospital for Joint Diseases).
• Patients and families — patients seeking treatment at area hospitals, plus their families, create consistent demand for medical practices, urgent care, pharmacies, and patient-serving retail.
• Local residents — dense residential population of Murray Hill, Kips Bay, Gramercy Park, and Midtown East, including young professionals, families, medical professionals, and longtime residents.
• Office workers — thousands of professionals employed in nearby Midtown East corporate offices.
• Commuters — tens of thousands of daily commuters passing through Grand Central Terminal and nearby transit hubs.
• Ideal for businesses such as:
• Fitness center (gym, yoga, Pilates, cycling)
• Medical or dental practice (primary care, pediatrics, dermatology, dentistry, orthodontics)
• Urgent care or walk-in clinic
• Physical therapy or rehabilitation center
• Pharmacy or drugstore
• Specialty food market or grocery
• Showroom or design studio
• Beauty or nail salon
• Coffee shop or cafe (patient and staff-friendly)

Highlights:
✔ 7,535 SF of expansive retail space on First Avenue in Murray Hill / Midtown East
✔ $120,000/month — premium location at $15.93 per square foot
✔ Attractive storefront with excellent visibility on a busy commercial corridor
✔ Steps from NYU Langone, Bellevue, VA Hospital, and Grand Central Terminal
✔ High ceilings and open floor plan — ideal for fitness, medical, urgent care, or market
✔ Loading access available
✔ Diverse, high-demand customer base — medical professionals, patients, residents, and commuters
✔ Excellent transit access — 4, 5, 6, 7, S, B, D, F, M, N, Q, R, W, 1, 2, 3 trains, Grand Central, Penn Station

Conclusion:

626 First Avenue offers a prime opportunity for healthcare providers, fitness operators, and large-format retailers seeking premium, expansive retail space in one of Manhattan’s most convenient, centrally located, and desirable neighborhoods — Murray Hill / Midtown East, steps from NYU Langone Medical Center, Bellevue Hospital, and Grand Central Terminal. With 7,535 SF of functional, flexible space, a prime First Avenue location in the heart of a major medical and commercial corridor, and access to a loyal, high-demand customer base of medical professionals, patients, residents, and commuters, this property is perfect for fitness centers, medical and dental practices, urgent care centers, physical therapy clinics, pharmacies, or grocery markets looking to thrive in a location where healthcare, commerce, and convenience intersect — at a premium price befitting this prime location.

Contact us today to schedule a private tour and secure this premier Murray Hill / Midtown East retail space!