Retail

Prime Retail Space on the Upper East Side – 345 E 69th Street

Address: 345 E 69th Street, New York, NY, 10021
Price: $30,000/month
Square Feet: 1,312 SF
Type: Retail Space

Property Overview:

Located in the heart of the Upper East Side, 345 E 69th Street offers 1,312 SF of premium retail space in one of Manhattan’s most desirable residential neighborhoods. Ideal for medical and dental practices, boutique fitness studios, specialty food markets, pharmacies, beauty salons, or service-based businesses catering to an affluent local clientele. Situated between First Avenue and York Avenue, this space benefits from proximity to world-class medical institutions, luxury residential buildings, and strong daily foot traffic from residents, medical professionals, and patients.

Key Features:

Prime Upper East Side / Lenox Hill Location:

• Situated on East 69th Street, a quiet, tree-lined residential block in the heart of the Upper East Side’s Lenox Hill neighborhood — one of Manhattan’s most prestigious and sought-after residential areas.
• Located between First Avenue and York Avenue, two busy north-south corridors lined with retail, restaurants, pharmacies, and daily conveniences.
• Minutes from the East River and Carl Schurz Park (68th-70th Streets), a beloved waterfront green space attracting families, dog walkers, joggers, and children daily.
• Surrounded by a mix of luxury co-ops and condominiums, pre-war townhouses, and world-class medical institutions.
• Short walk to Second Avenue’s Q subway line, Third Avenue’s retail corridor, Lexington Avenue’s boutique shopping, and Madison Avenue’s luxury flagships.

Medical & Institutional Proximity – A Healthcare Hub:

• Located within blocks of some of New York City’s most prestigious medical institutions:
• Weill Cornell Medical Center (68th Street and York Avenue)
• NewYork-Presbyterian Hospital (68th Street and York Avenue)
• Hospital for Special Surgery (HSS) (70th Street and York Avenue) — #1 in orthopedics nationwide
• Memorial Sloan Kettering Cancer Center (67th-68th Streets on York Avenue)
• Rockefeller University (66th-68th Streets on York Avenue)
• This concentration of world-renowned hospitals and research centers creates consistent, high-demand foot traffic from medical professionals, hospital employees, patients, families, and caregivers — all needing nearby services and amenities.

Spacious & Versatile Retail Layout:

• 1,312 SF of generous retail space — perfectly sized for a medical practice, dental office, fitness studio, specialty market, or service-based business.
• Attractive storefront with good street-level visibility on a quiet residential block with steady foot traffic.
• Open floor plan with high ceilings, allowing for easy customization to fit various business needs — from exam rooms and reception areas to retail displays and fitness equipment.
• Large windows providing abundant natural light — a valuable feature for patient-facing medical practices and wellness studios.
• Potential for multiple private offices, exam rooms, a reception/waiting area, break room, and storage.
• At $22.86 per square foot, this price reflects the premium associated with a prime Upper East Side location in close proximity to world-class medical institutions.

Excellent Transit Access:

• Close to the 68th Street – Hunter College subway station (6) on Lexington Avenue (approximately a 10-minute walk).
• Short walk to the 72nd Street station (Q) on Second Avenue, providing a direct connection to Midtown and downtown via the Second Avenue Subway.
• Multiple bus routes serve First Avenue, York Avenue, 68th Street, and 72nd Street (M15, M31, M66, M72, M79-SBS).
• Convenient for Upper East Side residents, medical professionals, hospital employees, patients, and their families.

Affluent, Loyal & High-Demand Customer Base:

• The Lenox Hill neighborhood is home to some of New York City’s wealthiest and most established residents, including medical professionals, finance executives, lawyers, philanthropists, and families.
• The proximity to four world-class hospitals creates significant demand for medical and dental practices, urgent care centers, physical therapy clinics, pharmacies, and patient-amenity retail (e.g., coffee shops, delis, gift shops, florists, optical shops).
• Strong daytime foot traffic from hospital employees, home healthcare workers, residents, and patients/families seeking services and amenities.
• The neighborhood’s strong sense of community and loyalty to local businesses make it ideal for businesses that rely on repeat clientele and word-of-mouth referrals.
• Unlike the luxury retail corridors of Madison or Fifth Avenues, this location offers essential, everyday retail opportunities with less competition and more reasonable rents.
• Ideal for businesses such as:
• Medical or dental practice (primary care, pediatrics, dermatology, dentistry, orthodontics, ophthalmology)
• Urgent care or walk-in clinic
• Physical therapy or rehabilitation center
• Pharmacy or drugstore
• Boutique fitness or yoga studio
• Specialty food market or gourmet grocery
• Beauty or nail salon
• Pet supply or grooming
• Coffee shop or café (patient and staff-friendly)
• Optical or eyewear shop
• Hearing aid or audiology practice
• Florist or gift shop (hospital-adjacent)

Highlights:
✔ 1,312 SF of premium retail space on the Upper East Side
✔ $30,000/month — competitive at $22.86 per square foot for a medical-adjacent location
✔ Attractive storefront on a quiet, tree-lined residential block
✔ Blocks from Weill Cornell, NY-Presbyterian, HSS (#1 orthopedics), and Memorial Sloan Kettering
✔ Ideal for medical/dental practices, physical therapy, pharmacy, or fitness studio
✔ Open floor plan with high ceilings and abundant natural light
✔ Affluent, loyal local residential customer base plus hospital employees and patients
✔ Convenient transit access — 6 and Q trains, multiple bus routes

Conclusion:

345 E 69th Street offers an outstanding opportunity for healthcare providers and small business owners seeking premium retail space in one of the Upper East Side’s most desirable medical-adjacent locations. With 1,312 SF of flexible, light-filled space, a prime Lenox Hill address steps from four world-class hospitals, and access to an affluent, loyal, and high-demand customer base of residents, medical professionals, and patients, this property is perfect for medical and dental practices, physical therapy clinics, pharmacies, boutique fitness studios, or patient-serving retail concepts looking to thrive in the heart of Manhattan’s premier healthcare corridor.

Contact us today to schedule a private tour and secure this premier Upper East Side retail space!