1255 Fifth Avenue — Massive Corner Retail / Medical / Community Facility Across from Central Park

Asking Rent: $30,000/month
Size: ±9,000 SF
Type: Retail / Medical / Community Facility / Institutional / Office
Location: Fifth Avenue between East 106th & 107th Street | Upper Carnegie Hill / East Harlem

Space Overview

Introducing 1255 Fifth Avenue, an extraordinary 9,000-square-foot commercial opportunity situated directly across from Central Park. This expansive, ground-floor space offers a rare combination of scale, prestige, and location, making it perfect for medical facilities, educational institutions, cultural organizations, wellness centers, fitness studios, galleries, or large-format retail.

With impressive ceiling heights, structural flexibility, and wide window lines along Fifth Avenue, the space offers excellent light, visibility, and branding potential. The property’s footprint allows for multiple configurations—including reception areas, private offices, open workspaces, classrooms, treatment rooms, or large communal environments.

This is a standout opportunity for mission-driven organizations or operators requiring substantial square footage in an iconic Manhattan setting.

Key Features

• ±9,000 SF of contiguous commercial space
• Prestigious Fifth Avenue address directly across from Central Park
• Expansive frontage with excellent visibility
• Flexible layout suitable for large programming and multi-room setups
• High ceilings & significant open areas
• Potential for multiple entrances
• HVAC
• Private restrooms
• Elevator building
• Ideal for medical, educational, nonprofit, gallery/museum space, wellness, or institutional use

Location

Located on the border of Upper Carnegie Hill and East Harlem, 1255 Fifth Avenue offers both prestige and accessibility. The space is surrounded by cultural landmarks, residential developments, schools, and major park attractions.

Nearby highlights include:

• Central Park Conservatory Garden
• Museum Mile (including The Museum of the City of New York & The Jewish Museum)
• Mount Sinai Hospital
• Harlem Meer & North Woods
• Columbia University expansion zones
• Newly developed residential towers and co-ops

Transit access includes the 6 train at 103rd Street, the 4/5/6 at 125th Street, multiple bus lines on Fifth Ave/Madison Ave, and CitiBike stations nearby.

This corridor benefits from a steady mix of residents, students, healthcare professionals, museum visitors, office workers, and tourists.

Summary

1255 Fifth Avenue offers an exceptional 9,000-square-foot commercial footprint in a world-class location directly facing Central Park. Its scale, visibility, and flexibility make it ideal for organizations seeking a prestigious address with room to grow and the ability to create a significant presence in one of Manhattan’s most culturally rich neighborhoods.