Retail

For Lease – 355 East 72nd Street, New York, NY 10021

Asking Rent: $30,000 / Month
Available Space: 1,000 SF
Property Type: Retail / Medical Office
Lease Type: Direct Lease
Location: Upper East Side, Manhattan

Property Overview

Introducing 355 East 72nd Street, a 1,000-square-foot prime ground-floor commercial space available for $30,000 per month, ideally located in the heart of the Upper East Side. This rare offering provides exceptional frontage and visibility along one of the area’s most active residential and retail corridors—perfect for medical, wellness, beauty, or boutique retail tenants seeking high exposure in a prestigious neighborhood.

The space features a modern glass façade, efficient open layout, and high ceilings, offering excellent branding opportunities and flexible interior configurations. Situated in a mixed-use luxury building, the property enjoys strong foot traffic from surrounding residential towers, schools, and healthcare facilities.

Key Features

• Asking Rent: $30,000 / Month
• Available Space: 1,000 SF
• Property Type: Ground-Floor Retail / Medical Office
• Lease Type: Direct Lease
• Frontage: Wide glass storefront on East 72nd Street
• Ceiling Height: Approx. 11 FT
• Layout: Open retail plan with rear storage and restroom
• Condition: Move-in ready / modernized interior
• HVAC: Tenant-controlled
• Signage: Excellent visibility for branding
• Access: Street-level entry with ADA accessibility
• Building Type: Mixed-use residential and commercial building

Neighborhood Profile

Location Advantage:
Located between First and Second Avenues, 355 East 72nd Street benefits from high pedestrian activity and proximity to the Second Avenue Subway (Q line), which has transformed this corridor into one of the Upper East Side’s most desirable retail and professional zones. The area is surrounded by high-income residential populations, top-tier healthcare institutions, and boutique service businesses.

Lifestyle Appeal:
The Upper East Side combines affluence, stability, and consistent demand. Nearby landmarks include Weill Cornell Medical Center, Marymount Manhattan College, and the East River Esplanade, supporting steady local and commuter traffic. The area is home to a strong mix of cafés, pharmacies, medical offices, and boutique retailers.

Summary

The 1,000 SF ground-floor commercial space at 355 East 72nd Street, New York, NY 10021, is available for $30,000 per month under a direct lease. With high visibility, contemporary finishes, and a prime Upper East Side location, this property is ideal for medical, wellness, or boutique retail operators seeking premium exposure in one of Manhattan’s most stable and high-demand neighborhoods.