Retail

Premium Medical / Office / Retail Space in Gramercy – 301 East 22nd Street

Address: 301 East 22nd Street, New York, NY, 10010
Price: $35,000/month
Lease Type: Commercial Lease
Type: Medical Office / Wellness Center / Showroom / Professional Services
Location: Gramercy / Kips Bay – Near Third Avenue and Gramercy Park
Square Feet: 2,600 SF
Building Class: B+ (Mixed-Use Building with Ground-Floor Commercial Space)
Market Segment: Healthcare Providers, Wellness Brands, Private Practices, Law Firms, Financial Services

Property Overview:

301 East 22nd Street offers 2,600 SF of premium ground-floor commercial space in the heart of Gramercy, one of Manhattan’s most desirable and residentially dense neighborhoods. Ideal for medical, wellness, or high-end professional use, the space combines flexible layout potential with exceptional street visibility in a stable and affluent area.

Key Features:

Prime Gramercy Location:
✔ Situated near the corner of Third Avenue
✔ Surrounded by top medical institutions, residential co-ops, and luxury rentals
✔ Walking distance to Gramercy Park, NYU Langone, and Union Square

Well-Suited for Medical or Professional Use:
✔ 2,600 SF with high ceilings, large windows, and clean modern finishes
✔ Existing infrastructure for medical or therapy use (confirm with current buildout)
✔ Can also accommodate boutique retail, gallery, or educational/training centers
✔ Excellent for client-facing services or destination businesses

Accessibility & Transit:
✔ Close to 6, L, N, Q, R, and W subway lines
✔ Minutes to Union Square, Flatiron, and Midtown South
✔ High foot traffic area with strong residential and professional base

Highlights:

✔ $35,000/month for 2,600 SF of flexible, high-visibility space
✔ Ideal for medical, wellness, or professional firms
✔ Located in a quiet yet central corridor with upscale surroundings
✔ Available immediately with flexible lease structure

Conclusion:

301 East 22nd Street is a rare opportunity to secure high-end commercial space in the Gramercy area—a neighborhood known for its stability, affluence, and proximity to Manhattan’s key commercial and residential zones. Ideal for established professionals, health providers, or retail concepts seeking an elegant and efficient footprint.

Contact us today to schedule a private showing or request full leasing details.